Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-12-06
1998-06-09
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 3118
Patent
active
057634912
ABSTRACT:
Elevated intra-ocular pressure is reduced by administration directly to the eye of benzmetanide that inhibits function of a Na.sup.+ --K.sup.+ --2Cl.sup.-2 cotransporter mechanism discovered in trabecular meshwork cells of mammalian eyes. Benzmetanide is useful in treatment of diseases of the eye associated with elevated intra-ocular pressure, such as ocular hypertension and glaucoma.
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Palfrey, et al., "Inhibiton of Na-K-2Cl cotransport and bumetanide binding by ethacrynic acid, its analogues, and adducts," Am. J. Physiol., 264:C1270-C1277, 1993.
Brandt James D.
Curry Fitz-Roy E.
O'Donnell Martha E.
Spivack Phyllis G.
The Regents of the University of California
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