Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1994-12-09
1996-12-17
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 3119
Patent
active
055854010
ABSTRACT:
Elevated intraocular pressure is reduced by administration directly to the eye of compounds that inhibit function of a Na.sup.+ --K.sup.+ --2Cl.sup.-2 cotransporter mechanism discovered in trabecular meshwork cells of mammalian eyes. These compounds are useful in treatment of diseases of the eye associated with elevated intraocular pressure, such as ocular hypertension and glaucoma. A screening method is provided to discover additional compounds with utility for lowering intraocular pressure by substantially inhibiting the Na.sup.+ --K.sup.+ --Cl.sup.-2 cotransporter mechanism in trabecular meshwork cells.
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R. Greger, P. Wangemann, "Loop Diuretics," Renal Physiol., Basel 10:174-183, 1987.
Brandt, et al., "The Capillary Endothelium as an Experimental Model of the Outflow Pathways of the Eye," Invest. Ophthalmol. Vis. Sci., 35(4[Supp]):1848, 1994. Abstract.
Palfrey, et al., "Inhibition of Na-K-2Cl cotransport and bumetanide binding by ethacrynic acid, its analogues, and adducts," Am. J. Physiol., 264:C1270-C1277, 1993.
Edelman et al., Am. J. Physiology (266) (5 Part 1) C1210-C1221 (1994).
Brandt James D.
Curry Fitz-Roy E.
O'Donnell Martha E.
Spivack Phyllis G.
The Reents of the University of California
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