Method for enhancing magnetic resonance imaging using an image a

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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424 2, 436173, 436806, 514558, 514563, 514974, A61K 3120, A61K 31195, G01N 3100, G01N 2400

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active

050789864

ABSTRACT:
Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a substantially nontoxic paramagnetic image altering agent comprised of a composition containing a chelate of a paramagnetic element, such as manganese, gadolinium or iron, carried by a liposome. The chelate is carried by or within the external surface of the liposome in such a manner that after arrival at or delivery to the desired organ or tissue site, the paramagnetic image altering agent is released in a diagnostically useful fashion.

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Hart, M., U.S.A.E.C. Orins-12, 118-135 (1956).
Caride, V. J., Relaxation Enhancement Using Liposomes Carrying Paramagnetic Species Magnetic Resonance Imaging, 2:107-112 (1984).

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