Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-03-21
2006-03-21
Pak, Michael (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S04400A
Reexamination Certificate
active
07015190
ABSTRACT:
The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.
REFERENCES:
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Alberini, C. et al. (1994) C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell. 76:1099-1114 (Exhibit 2).
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Bartsch, Dusan et al. (1995) Alysia CREB2 Represses Long-term Facilitation: Relief of Repression Converts Transient Facilitation into Long-term Functional and Structural Change. Cell. 83:979-992 (Exhibit 4).
Bourtchuladze, R. et al. (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP responsive element-binding protein. Cell. 79:59-68 (Exhibit 5).
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Yin, J.C.P. et al. (1995) CREB as a Memory Modulator: Induced Expression of a dCREB2 Activator Isoform Enhances Long-term Memory in Drosophila. Cell. 81:107-115 (Exhibit 9).
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European Search report issued Jan. 28, 2005 in connection with European Patent Application No. 979268962, (do not publish).
Bartsch Dusan
Ghirardi Mirella
Kandel Eric R.
Pak Michael
The Trustees of Columbia University in the City of New York
White, Esq. John P.
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