Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-09-02
1991-10-22
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514 2, 424105, A61K 3724, A61K 3736
Patent
active
050595865
ABSTRACT:
The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.
REFERENCES:
patent: 4011312 (1977-03-01), Reuter et al.
patent: 4521409 (1985-06-01), Bauman et al.
Peel, J. Nutr., 111, 1662-1671 (1981).
Bauman, Commonwealth Agricultural Bureau, Abst. No. 85009653 (1984).
Michael, Chem. Abst., 102, 56(1985), Abst. No. 160488t.
Merriam-Webster Dictionary, 3rd. New International Dictionary, G & C Merriam Co., Springfield, Mass., 1967, p. 434.
R. Akers et al. (1981) Endocrinology 109:23-30 "Prolactin Regulation of Milk Secretion and Biochemical Differentation of Mammary Epithelial Cells in Periparturient Cows".
R. Akers (1985) J. Dairy Sci. 68:501-519, "Lactogenic Hormones: Binding Sites, Mammary Growth, Secretory Cell Differentiation and Milk Biosynthesis in Ruminants".
C. W. Welsch et al. (1979), Cancer Research 39:2046-2050 Hormone-Induced Growth and Lactogenesis of Grafts of Bovine Mammary Gland Maintained in the Athymic "Nude" Mouse.
Imagawa, W., et al., "Serum-Free Growth of Normal and Tumor Mouse Mammary Epithelial Cells in Primary Culture", 79 Proc. Natl. Acad. Sci. U.S.A. 4074-77 (1982).
Taketani, Y., et al., "Epidermal Growth Factor Stimulates Cell Proliferation and Inhibits Functional Differentiation of Mouse Mammary Epithelial Cells in Culture", 113(3) Endocrin. 871-77 (1983).
Taketani, Y. et al., "Biological Action of Epidermal Growth Factor and its Functional Receptors in Normal Mammary Epithelial Cells", 80 Proc. Natl. Acad. Sci, U.S.A. 2647-50 (1983).
Tonnelli, Q. J. et al., "Epidermal Growth Factor Requirement for Development of Cultured Mammary Gland", 285 Nature 250-52 (1980).
Turkington, R. W., "The Role of Epithelial Growth Factor in Mammary Gl and Development in Vitro", 57 Exper. Cell Res. 79-85 (1969).
Yang, J. et al., "Growth Factor-and Cyclic Nucleotide-Induced Proliferation of Normal and Malignant Mammary Epithelial Cells in Primary Culture".
Pasco, D., et al., "Effect of Hormones and EGF on Proliferation of Rat Mammary Epithelium Enriched for Alveoli", 141 Exper. Cell Res. 313-24 (1982).
McGrath, M. et al., "Differential Response of Normal Rat Mammary Epithelial Cells to Mammogenic Hormones and EGF", 125 J. Cell Physiology 182-91 (1985).
Kidwell, W. R. et al., "Purification of a Mammary-Derived Growth Pactor from Human Milk and Human Mammary Tumors", 260(9) J. Biol. Chem. 5745-52 (May 10, 1985).
Lyons, W. R., "The Direct Mammotrophic Action of Lactogenic Hormone", 51 Proc. Soc. Exptl. Biol. Med. 308-311 (1942).
Fiddler et al., "Effects of Intraductal Prolactin on Some Aspects of the Ultrastructure and Biochemistry of Mammary Tissue in the Pseudopregnant Rabbit", 49 J. Endocrin. 459-69 (1971).
Bradley et al., "The Response of Rabbit Mammary Glands to Locally Administered Prolactin", 14 J. Endocrin. 28-36 (1956).
Meites et al., "The Introduction of Lactation During Pregnancy in Rabbits and the Specificity of the Lactogenic Hormone", 150 Amer. J. Physiol., 394-99 (1947).
Spinelli, J. S. et al., "Drugs in Veterinary Practice", C. V. Mosby Co., St. Louis, Mo. (1978).
Lyons et al., "The Hormonal Control of Mammary Growth and Lactation", 14 Recent Prog. Hormone Res. 219-54 (1958).
Daniel et al., "Reinitiation of Growth in Senescent Mouse Mammary Epithelium in Response to Cholera Toxin", 224 Sci. 1245-47 (1984).
Siberstein et al., "In Vivo, cAMP Stimulantes Growth and Morphogenesis of Mouse Mammary Ducts", 81 Proc. Natl. Acad. Sci. U.S.A. 4950-54 (1984).
Collier Robert J.
McGrath Michael F.
Beck George R.
Clayman Carol H.
Moezie F. T.
Monsanto Company
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