Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-07-01
1999-10-12
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 435325, 435348, 435456, C12N 1586, C12N 510, C12P 2100
Patent
active
059653930
ABSTRACT:
The baculovirus homologous region (hr1) sequence has been disclosed as a transcriptional enhancer of foreign gene expression. An additional copy of the hr1 element contained within a recombinant baculovirus has been demonstrated to be capable of further enhancing expression of foreign genes placed under the transcriptional control of a promoter such as the baculovirus polyhedrin and/or Drosophila hsp70 promoter. The recombinant baculovirus is stable for up to 30 passages. This invention can be employed to generate recombinant expression vector plasmids and recombinant baculoviruses that can be used to produce increased levels of recombinant protein products of therapeutic, biomedical or basic science research interest.
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Guarino, Linda A. et al., "Complete Sequence and Enhancer Function . . . " Journal of Virology, vol. 60, No. 1 Oct. 1986, pp. 224-229.
Habib Saman
Hasnain Seyed E.
Venkaiah Betapudi
Guzo David
National Institute of Immunology
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