Method for enhancing analysis timing in kinetic nephelometry

Details Method for enhancing analysis timing in kinetic nephelometry Method for enhancing analysis timing in kinetic nephelometry

1985-12-23

1989-05-30

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving kinetic measurement of antigen-antibody reaction

356338, 356341, 436536, 436805, 436909, G01N 33557, G01N 3500

Patent

active

048351105

ABSTRACT:
The peak verify time for kinetic nephelometric measurements of reactions between antigens and antibodies is adjusted as a function of the magnitude of the peak rate order to reduce the time required for peak verification. The scatter signal is zeroed following the end of the peak verification period and the reaction is tested for antigen excess. Reactions during the antigen excess check having rates that exceed a threshold value are accepted as being valid, and no additional measurements are made for such samples. Reactions during the antigen excess check having rates that are less than the threshold value are rejected as being in antigen excess. Samples found to be in antigen excess are diluted and then reanalyzed.

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patent: 4521521 (1985-06-01), Abbott
patent: 4539295 (1985-09-01), Blough, Jr.
patent: 4618485 (1986-10-01), Tsay

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