Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-10-28
1997-05-13
Jones, W. Gary
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 5, 435 6, 536 245, 514 44, C12P 1934, C12Q 170, C12Q 168, C07H 2104
Patent
active
056291787
ABSTRACT:
A process for producing a particular nucleic acid sequence from a given sequence of DNA or RNA in amounts which are large compared to the amount initially present, using PNAs in conjunction with the polymerase chain reaction (PCR) is disclosed.
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Michael Egholm, et al., "Peptide Nucleic Acids (PNA). Oligonucleotide Analogues with an Achiral Peptide Backbone", J. Am. Chem. Soc. 1992, 114, 1895-1897.
Seog K. Kim, et al., "Right-Handed Triplex Formed between Peptide Nucleic Acid PNA-T.sub.8 and Poly(dA) Shown by Linear and Circular Dichroism Spectroscopy", J. Am. Chem. Soc. 1993, 115, 6477-6481.
Michael Egholm, et al., "Peptide Nucleic Acids containing Adenine or Guanine recognize Thymine and Cytosine in Complementary DNA Sequences", J. Chem. Soc. Chem. Comm., 1993, 800-801.
Kim L. Deuholm, et al., "An Efficient Synthesis of Boc-Aminoacetaldehyde and its Application to the Synthesis of N-(2-BOC-Aminoethyl)Glycine Esters", Organic Preparations and Procedures Int., 25(4), 457-461 (1993).
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Birgitte Hyrup, et al., "Modification of the Binding Affinity of Peptide Nucleic Acids (PNA). PNA with Extended Backbones consisting of 2-Aminoethyl-.beta.-alanine or 3-Aminopropylglycine Units", J. Chem. Soc. Commun. 1993, 518-519.
Michael Egholm, et al., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules", Nature, vol. 365, 566, 7 Oct. 1993.
Jeffery C. Hanvey, et al., "Antisense and Antigene Properties of Peptide Nucleic Acids", Science, vol. 258, 1481, 27 Nov. 1992.
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Saiki, In PCR Protocols: A Guide to Methods and Appplications, Academic Press, 1990, pp. 13-20.
WO94/28171, PNA Diagnostics, Stanley, Nucleic Acid Analog Assay Procedures., 8 Dec. 1994.
Drum et al., Nucleic Acids Research 21:5332-5336,. 1993.
Genetics & IVF Institute
Jones W. Gary
Rees Dianne
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