Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1993-02-16
1996-07-30
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424 851, 4241841, 4242781, 435 704, 514168, 514171, 514179, A61K 3156, A61K 3159, A61K 3820, A61K 3939
Patent
active
055409199
ABSTRACT:
Disclosed is a method for enhancing the production of T cell lymphokines, which comprises exposing T cell lymphocytes which have a potential to make selected T cell lymphokines to an appropriate concentration of at least one particular steroid hormone prior to cellular activation. Also disclosed are applications of the method for clinically diagnosing abnormal interleukin production, maintaining in vitro tissue cultures of T cells, overcoming certain types of immunosuppression caused by elevated GCS levels, caused by endogenous production or exogenous administration, use as a vaccine adjuvant to selectively direct the vaccine-induced immune response down a protective, rather than a potentially pathologic or non-protective, immunologic pathway, as a treatment for naturally occuring aging-related decreases in immune function, as a treatment for stress or trauma-induced decreases in immune function, and as an agent to facilitate desensitization to agents to which a warm-blooded animal is allergic.
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Araneo Barbara A.
Daynes Raymond A.
Russel Jeffrey E.
University of Utah Research Foundation
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