Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1990-03-28
1992-04-28
Doll, John
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435243, 935 52, 514 2, 514 44, C12N 500, C12N 100, A61K 3702, A61K 3170
Patent
active
051089211
ABSTRACT:
A method is provided for enhancing transmembrane transport of exogenous molecules. The method comprises contacting a membrane of a living cell with a complex formed between said molecules and ligands selected from biotin, biotin analogs and other biotin receptor-binding ligands, and/or folic acid, folate analogs and other folate receptor-binding ligands to initiate receptor mediated transmembrane transport of the ligand complex. The method is used for the efficient delivery of peptides, proteins, nucleic acids and other compounds capable of modifying cell function into plant, animal, yeast, and bacterial cells.
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This invention was made with Government support under Grant 89-45-DCB-88-11465, awarded by the National Science Foundation. The Government has certain rights in the invention.
Heinstein Peter F.
Horn Mark A.
Low Philip S.
Doll John
Elliott George C.
Purdue Research Foundation
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