Method for employing the delta opioid dadle to extend tissue sur

Details Method for employing the delta opioid dadle to extend tissue sur Method for employing the delta opioid dadle to extend tissue sur

1995-02-24

1997-08-12

Krass, Frederick

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

Including perfusion; composition therefor

424 75, A01N 102

Patent

active

056564201

ABSTRACT:
This invention concerns a method for extending the survival time of mammalian lung tissue subjected to ischemia, by which said tissue is perfused with a preservation solution comprising a therapeutic dose of the delta opioid DADLE ([D-Ala.sup.2,D-Leu.sup.5 ]-Enkephalin) under hypothermic conditions.

REFERENCES:
Su et al., "Novel Actions of a Delta Opoid Peptide DADLE: From Hibernation to Organ Preservation", Society For Neuroscience Abstracts, 19(1-3) p. 421 (1993).
Wuethrich, B., "Organs Last Longer with Opiates", New Scientist, vol. 140, No. 1902, p. 20, Published Dec. 1993.
Chien et al., "Extension of Tissue Survival Time in Multiorgan Block Preparation with a Delta Opoid DADLE", The Journal of Thoracic and Cardiovascular Surgery, 107(3), pp. 964-967, Mar. 1994.
Hibernation Induction Trigger for Organ Preservation, Chapter 5, pp. 88-104, Extending Organ Survival Time Using Delta Opioid (DADLE), Sufan Chien, MD. Peter R. Oeltgen, Ph.D.
Life Sciences, vol. 46, pp. 1279-1286, Sigma And Opioid Receptors In Human Brain Tumors, Gail E. Thomas et al.
The Journal of Thoracic and Cardiovascular Surgery, vol. 103, No. 6, Jun., 1992, pp. 1136-1142, Reliable eighteen-hour lung preservation at 4.degree. and 10.degree.C by pulmonary artery flush after high-dose prostaglandin E.sub.1 administration, Eckhard Mayer, MD et al.
The Journal of Thoracic and Cardiovascular Surgery, vol. 95, No. 1, Jan., 1988, pp. 55-61, A simple technique for multiorgan preservation, Sufan Chien, MD et al.

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