Method for elucidation and detection of polymorphisms, splice va

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 912, 536 2431, 536 2433, C12Q 168, C12P 1934, C07H 2104

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active

060836946

ABSTRACT:
A method of detecting polymorphisms in the S182 gene by detecting mutations in the S182 gene using selected mismatched PCR primers comprising sequences derived from intronic sequences of the S182 gene is provided. A method of identifying an individual susceptible to late onset Alzheimer's Disease is also provided.

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Rogaev et al. "Familial Alzheimer's disease in kindreds with missense mutations in a gene on Chromosome 1 related to the Alzheimer's disease type 3 gene", Nature, vol. 376, pp. 775-778 (1995).
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Cai et al. American Journal of Medical Genetics. 74: 202-203, 1997.
Scott et al. Genetic Epidemiology. 14:307-315, 1997.
Clark et al. Nature Genetics. 11:219-222, Oct. 1995.

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