Chemistry: molecular biology and microbiology – Apparatus
Reexamination Certificate
2011-01-18
2011-01-18
Negin, Russell S (Department: 1631)
Chemistry: molecular biology and microbiology
Apparatus
C435S006120, C422S050000
Reexamination Certificate
active
07871811
ABSTRACT:
The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods include (1) physically deteriorating/removing the waveguide film between individual biosensors; (2) chemically depositing highly absorbing materials within the waveguide film between individual biosensors; (3) patterning disordered (scattering) regions between the diffraction gratings that define individual biosensors; (4) using a specific mask and depositing individual patches of waveguide film, where each patch defines at least one biosensor. Each of these methods and several other methods described herein prevent the propagation of light between individual sensing regions, thereby eliminating optical crosstalk between the biosensors. The present invention also includes the resulting microplate.
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Fang Ye
Ferrie Ann M.
Fontaine Norman H.
Frutos Anthony G.
Mozdy Eric J.
Beall Thomas R.
Butler Gregory B.
Corning Incorporated
Negin Russell S
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