Method for effecting vasodilation with monoglycerides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514549, 514552, 514912, A61K 3122, A61K 3123

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active

053067290

ABSTRACT:
The invention provides a novel method of effecting vasodilation in a warm-blooded animal in need of such treatment and involves administering to a warm-blooded animal an effective amount of a vasodilatory monoglyceride of the formula: ##STR1## wherein R is a straight or branched chain aliphatic hydrocarbyl substituent of 2-7 carbon atoms, preferably 3-5 carbon atoms, which is saturated or unsaturated, and which is substituted or unsubstituted with one or more substituents that do not interfere with vasodilatory activity.

REFERENCES:
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Okumura et al., "Effect Of Monoglycerides On The Percutaneous Absorption Of Papaverine Hydrochloride", Drug Design and Delivery, 6:137-148 (1990).

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