Method for early detection of allograft rejection

Details Method for early detection of allograft rejection Method for early detection of allograft rejection

1991-08-16

1993-06-29

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 5303913, A61K 4902, A61K 4300, C07K 1528

Patent

active

052232417

ABSTRACT:
The invention relates to a method of detecting early rejection of an allograft in a mammal by administering to the mammal a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site of allograft rejection. The method of the invention may also be used to monitor allograft rejection during immunosuppressive therapy in a mammal which has received an allograft or to localize areas involved in autoimmune disease or inflammation.

REFERENCES:
patent: 4864020 (1989-09-01), Canle et al.
patent: 4925648 (1990-05-01), Hanssen et al.
patent: 5002869 (1991-03-01), Schlossman et al.

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