Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-06-06
2006-06-06
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S192100, C424S195110, C424S184100
Reexamination Certificate
active
07056512
ABSTRACT:
Disclosed are novel methods for increasing muscle mass by means of immunization against Growth Differentiation Factor 8 (GDF-8, myostatin). Immunization is preferably effected by administration of analogues of GDF-8 which are capable of inducing antibody production against homologous GDF-8. Especially preferred as an immunogen is homologous GDF-8 which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes while substantially preserving the tertiary structure of the homologous GDF-8. Also disclosed are nucleic acid vaccination against GDF-8 and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for identification of useful immunogenic GDF-8 analogues, methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
REFERENCES:
patent: 6369201 (2002-04-01), Barker et al.
patent: 6607884 (2003-08-01), Lee et al.
patent: 2333706 (1999-08-01), None
patent: WO 95/05849 (1995-03-01), None
patent: WO 95/07707 (1995-03-01), None
patent: WO 98/23635 (1998-06-01), None
patent: WO 98/46642 (1998-10-01), None
patent: WO9902667 (1999-01-01), None
patent: WO9942573 (1999-08-01), None
Colman et al., Research in Immunology 145(1):33-36, 1994.
Abaza et al., Journal of Protein Chemistry 11(5):433-444, 1992.
Lederman et al in Molecular Immunology 28:1171-1181, 1991.
Van Regenmortel, A Comparion to Methods of Enzymology 9:465-472, 1996.
Biochemistry 37 (16)(1998) 5709-19 Wearsch et al “Structural Transitions accompanying the activation of peptide binding”.
Journal of Immunology 160 (1998) 3363-73 Southwood et al “Several common HLA-DR types share largely overlapping peptide binding repertoires”.
Annu Rev Immunol 15 (1997) 617-48 Donnelly et al “DNA vaccines”.
Life Sciences 60 (3) (1997) 163-72 Donnelly et al “Mini Review: DNA Vaccines”.
Nature 387 (May 1, 1997) 83-89 McPherron et al Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member.
Proc Natl Acad Sci USA 94 (Nov. 1997) 12457-61 McPherron et al “Double muscling in cattle due to mutations in the myostatin gene”.
Immunology and Cell Biology 74 (1996) 8-25 Barr et al “ISCOMs (immunostimulating complexes): The first decade”.
Journal of Immunology 157 (1996) 4796-4804 Dalum et al “Breaking of B cell tolerance toward a highly conserved self protein”.
Science 271 (Jan. 19, 1996) 348-50 Dempsey et al “C3d of complement as a molecular adjuvant: bridging innate and acquired immunity”.
Clin Immunother 3 (6) (1995) 461-75 Morein et al “Immunostimulating complexes”.
La Revue du Praticien (Paris) 45 (1995) 1492-96 Saliou P “Les vaccins vivants”.
Immunity 1 (9) (Dec. 1994) 751-61 Alexander et al Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides.
Immunogenetics 39 (1994) 230-42 Falk et al “Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of . .”
Cell 74 (Jul. 16, 1993) 197-203 Hammer et al Promiscuous and Allele-specific anchors in HLA-DR-binding peptides.
J Exp Med 178 (Jul. 1993) 27-47 Chicz et al “Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles”.
J Immunol 149 (11) (Dec. 1, 1992) 3477-81 Gosselin et al “Enhanced antigen presentation using human Fc gamma receptor . .”.
Vaccine 10 (14) (1992) 977-90 Walker PD “Bacterial vaccines: old and new, veterinary and medical”.
Nature 336 (22/29) (Dec. 1988) 778-80 Sinigaglia et al “A malaria T cell epitope recognized in association with most mouse and human MHC class . .”.
Bo Meng and Dahai Zhu, “Myostatin Regulates Skeletal Muscle Cell Differentiation in Chicken Primary Myoblast Cells”, Molecular and Cellular Developmental Biology Laboratory Harbin Institute of Technology, Harbin, 150001.
Halkier Torben
Klysner Steen
Mouritsen Soren
Belyavskyi Michail A.
Birch Stewart Kolasch & Birch, LLP.
Chan Christina
Pharmexa A/S
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