Method for dose mapping to ensure proper amounts of gamma irradi

Details Method for dose mapping to ensure proper amounts of gamma irradi Method for dose mapping to ensure proper amounts of gamma irradi

1998-05-28

2000-12-05

Hannaher, Constantine

Radiant energy

Calibration or standardization methods

250580, G01T 100

Patent

active

061570281

ABSTRACT:
A method of dose mapping that simulates actual product irradiation conditions utilizing a semisolid to fix dosimeter (18) inside product containers (14) and a dry ice substitute (16) to mimic the density of dry ice. The method comprising the steps of fixing dosimeter (18) in a semisolid mixture inside product containers (14) packed with a dry ice substitute (16) and irradiating. The results are then calculated and analyzed to produce an accurate dose map.

REFERENCES:
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Note for Guidance: Good Manufacturing Practice for Medicinal Products: Use of ionizing radiation in the manufacture of medicinal products Annex 12, "Guide to good manufacturing practice for medicinal products", Directive 91/356. EEC, Jun. 13, 1991.
"Dose determination by Monte Carlo--a useful tool in gamma radiation process", C. Oliveira, J. Salgado, M. Luisa Botelho, L.M. Ferreira, Radiation Physics and Chemistry 57 (2000), p. 667-670.
H. Levine et al., "Temperature and Humidity Effects on the Gamma-Ray Response and Stability of Plastic and Dyed Plastic Dosimeters," Radiat. Phys. Chem., vol. 14, 1979, pp. 551-574.
M.C. Saylor et al., "A Thin Film Recording Medium for Use in Food Irradiation," Radiat. Phys. Chem., vol. 31, Nos. 4-6, 1988, pp. 529-536.
S. Biramontri et al., "Effect of Low Irradiation Temperature on the Gamma-Ray Response of Dyed and Undyed PMMA Dosimeters," Radiat. Phys. Chem., vol. 48, No. 1, 1996, pp. 105-109.

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