Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Chemical stimulation of growth or activity by addition of...
Patent
1991-08-29
1993-02-09
Griffin, Ronald W.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Chemical stimulation of growth or activity by addition of...
4352523, 4352401, 424573, 536 187, 540545, C12N 138
Patent
active
051852608
ABSTRACT:
A G.sub.1 phase kinase inhibitor is applied in a low concentration to a population of normal and transformed mammalian cells. The concentration of G.sub.1 phase kinase inhibitor is selected to reversibly arrest normal mammalian cells in the G.sub.1 cell cycle without arresting growth of transformed cells. The transformed cells may then be selectively identified and/or cloned for research or diagnostic purposes. The transformed cells may also be selectively killed by therapeutic agents that do not affect normal cells in the G.sub.1 phase, suggesting that such G.sub.1 phase kinase inhibitors may form an effective adjuvant for use with chemotherapeutic agents in cancer therapy for optimizing the killing dose of chemotherapeutic agents while minimizing undesirable side effects on normal cells.
REFERENCES:
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Kiyoto, Itsumi et al., "Staurosporine". . . in Biochem. and Biophys. Res. Comm., 148:2, pp. 740-746, 1987.
Calabretta, Bruno et al., "Expression of c-myc . . . ," Cancer Research, vol. 45, pp. 6000-6004, 1985.
Bradbury E. Morton
Crissman Harry A.
Gadbois Donna M.
Tobey Robert A.
Gaetjens Paul D.
Griffin Ronald W.
Moser William R.
The United States of America as represented by the United States
Webber Pamela S.
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