Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...
Patent
1996-05-15
2000-02-22
Adams, Donald E.
Chemistry: analytical and immunological testing
Nuclear magnetic resonance, electron spin resonance or other...
324309, 324311, 324313, 324314, 435 71, G01N 2400, G01V 300
Patent
active
060279419
ABSTRACT:
This invention includes methods for analyzing data generated by various solid-state NMR experiments, including rotational echo double resonance (REDOR), transferred echo double resonance (TEDOR), dipolar recoupling at the magic angle (DRAMA), dipolar recoupling with a windowless sequence (DRAWS), and melding of spin-locking and DRAMA (MELODRAMA). The methods are based alternately on a new analytical transform or the maximum entropy method and their multi-dimensional extensions. They permit simultaneous, multiple distance measurements of high accuracy and precision, even from nuclei with identical chemical shifts. By providing high quality easily obtained distance measurement from disordered solid state materials, this invention also improves drug discovery and design through fast determination of structures of pharmaceutical lead compounds, drug molecules, or their targets.
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Bader Joel S.
Jarvie Thomas P.
Went Gregory T.
Adams Donald E.
CuraGen Corporation
Ricigliano Joseph W.
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