Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-09-15
1995-12-26
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31155
Patent
active
054788641
ABSTRACT:
A novel disinfectant is disclosed. Said disinfectant is a compound 1,n-bis(N.sup.5 -m-, or p-trifluoromethyl-phenyl-N.sup.1 -biguanido)-C.sub.3 -C.sub.10 -alkane. The m-trifluoro-C.sub.6 derivative is a known compound. The compounds of the present invention exhibit germicidal effect against Pseudomonas aeruginosa, Proteus vulgaris and Alcaligenes faecalis at concentrations of 1/4-1/8 of the effective concentration for chlorhexidine. Against other microorganisms, the compounds are effective at the same level as chlorhexidine.
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Rose and Swain, Bisdiguanides having Antibacterial Activity, J.Chem. Soc., Jun. 19, 1956, pp. 4422-4425.
Warner & Lynch, Quantitative Structure-Activity Relationships for Biguanides . . . , J. Medicinal Chemistry, 1979, vol. 22, No. 4, pp. 359-366.
P. Gjiermo et al., Effect on Dental Plaque Formation and Some In Vitro Properties of 12 Bis-biguanides J.periodont.Res. 8; Suppl. 12: 81-88, 1973.
A. M. Slee et al., Studies on the Relative Binding Affinities of Chlorhexidine Analogs to Cation Exchange Surfaces, J.periodont.Res. 14: 213-219, 1979.
J. M. Tanzer et al., Structural Requirements of Guanide, Biguanide, and Bisbiguanide Agents for Antiplaque Activity, Antimicrobial Agents and Chemotherapy, vol. 12, No. 6, Dec. 1977, pp. 721-729.
V. D. Warner et al., 1,6-Bis (N.sup.5 -m-trifluoromethylphenyl-N.sup.1 biguanido)-hexane and Related Analogs of Chlorhexide as Inhibitors of Dental Plaque, J. Medicinal Che., 1973, vol. 16,No. 6, pp. 732-733.
Harada Michio
Honda Tsunetoshi
Nakamura Akihiro
Nishihara Akira
Takizawa Maki
Bembenick B.
Conlin David G.
Corless Peter F.
Mitsubishi Materials Corp.
Robinson Allen J.
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