Method for discrimination of metaplasias from neoplastic or...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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10511108

ABSTRACT:
The present invention relates to a method for discrimination of p16INK4aoverexpressing metaplasias from neoplastic or preneoplastic p16INK4aoverexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures. The method thus enables for reduction of false positive results in the p16INK4abased detection of anogenital lesions in cytological testing procedures.

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