Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 6 to 7 amino acid residues in defined sequence
Patent
1997-05-30
1999-01-12
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
6 to 7 amino acid residues in defined sequence
514 16, A61K 3808
Patent
active
058591885
ABSTRACT:
The present invention provides a novel radioactive neuropeptide represented by the formula Lys-His-Glu-Tyr.sup.--I -Leu-Arg-Phe-amide. The invention also provides a method for detecting anthelmintic activity of a compound using the novel neuropeptide of the present invention in a receptor binding assay. The novel radioactive neuropeptide has potent bioactivity in Ascaris suum neuromuscular strips, and therefore is particularly useful for high volume screening for potential anthelmintic compounds.
REFERENCES:
International Journal for Parasitology, vol. 25, No. 11, 1995, T.G. Geary et al., "The Pharmacology of FMRFamide-Related Neuropeptides in Nematodes: New Opportunities for Rational Anthelminit Discovery?", pp. 1273-1280.
Keating, Parasitology III, 515, 1995.
Marks, Biochem. Biophys. Res. Commun. 217, 845, 1996.
Bowman Jerry W.
Friedman Alan R.
Geary Timothy G.
Lukton David
Pharmacia & Upjohn Company
Tsang Cecilia J.
Yang Lucy X.
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