Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Patent
1997-02-03
2000-08-01
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
435 912, C12N 1500, C12P 1934
Patent
active
060965487
ABSTRACT:
The invention provides a number of strategies for transferring and/or evolving gene(s) associated with cellular DNA uptake so that they confer or enhance DNA-uptake capacity of a recipient cell. Evolution is achieved by recursive cycles of recombination and screening/selection. One such strategy entails evolving genes that confer competence in one species to confer either greater competence in that species, or comparable or greater competence in a second species. Another strategy entails evolving genes for use as components of cloning vector to confer enhanced uptake of the vector. Other strategies entail evolving viral receptors, viruses, and genes that mediate conjugal transfer.
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Kruse Norman
Liebeschuetz Joe
Maxygen Inc.
Powers Margaret A.
Schwartzman Robert A.
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