Method for directed packaging of molecular substances in...

Details Method for directed packaging of molecular substances in... Method for directed packaging of molecular substances in...

2006-08-15

2006-08-15

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

C424S450000

Reexamination Certificate

active

07091028

ABSTRACT:
The invention relates to a method for packaging molecular substances in protein shells, comprising the following steps: binding a protein shell fragment, via a first region to a matrix; bringing the protein shell fragment bound to the matrix into contact with the molecular substance, in order to bind the molecular substance to a second region of the protein shell fragment; separating the protein shell fragment with the bonded molecular substance, or the part thereof which contains the bonded molecular substance, from the matrix and assembling the separated protein shell fragments, or the part thereof which contains the bonded molecular substance, with other protein shell fragments to form a protein shell, whereby the separation and assembly can be carried out in any order.

REFERENCES:
patent: 36 36 540 (1988-04-01), None
patent: WO 99/25324 (1999-05-01), None
Ou, W. et al.“The Major Capsid Protein, VP1, of Human JC Virus Expressed inEscherichia coliis Able to Self-assemble into a Capsid-like Particle and Deliver Exogenous DNA into Human Kidney Cells,”J. of General Virology1999, pp. 39-46, vol. 80.
Schneider, J. et al. “Inhibition of HIV-1 in Cell Culture by Synthetic Humate Analogues Derived from Hydroquinone: Mechanism of Inhibition,”Virology1996, pp. 389-395, vol. 218.

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