Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Patent
1993-03-15
1995-10-24
Housel, James C.
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
436175, 128638, 128759, 435 28, G01N 3372
Patent
active
054609690
ABSTRACT:
The presence of fecal occult blood in a stool sample is detected by mixing a liquid stool sample with an acidic liquid, such as a phosphate/citrate buffer, to precipitate hematin from the solution. The precipitated hematin is separated and the presence or absence of hemoglobin is determined by exposing the solution to a peroxidase diagnostic assay. A positive response indicates the presence of blood originating in the lower gastrointestinal tract, a leading indicator of lower GI cancer.
REFERENCES:
patent: 3718431 (1973-02-01), Wild
patent: 3996006 (1976-12-01), Pagano
patent: 4175923 (1979-11-01), Friend
patent: 4259964 (1981-04-01), Levine
patent: 4273741 (1981-06-01), Levine
patent: 4367750 (1983-01-01), Levine
patent: 4420353 (1983-12-01), Levine
patent: 4559949 (1985-12-01), Levine
patent: 4615982 (1986-10-01), Lawrence
patent: 4645743 (1987-02-01), Baker et al.
patent: 4789629 (1988-12-01), Baker et al.
patent: 4804518 (1989-02-01), Levine et al.
patent: 4808379 (1989-02-01), Wardlaw et al.
patent: 4849173 (1989-07-01), Chang
patent: 4956300 (1990-09-01), Wells
patent: 5064766 (1991-11-01), Wardlaw et al.
patent: 5094956 (1992-03-01), Grow et al.
patent: 5128452 (1992-07-01), Hai et al.
Lemberg et al., Hematin Compounds and Blue Pigments 1949 pp. 159-175, 223-225.
"Cytologic Detection of Colorectal Cancer After . . . ", by Gordon et al., pp. 106-110, Jul. 1, 1991.
"A Method of Obatining, Processing, and Analyzing . . . ", by Gaspari et al., Journal of Immun. Methods, pp. 85-91, 1988.
"Gut Lavage Fluid Proteins as Markers . . . ", by S. O'Mahony et al., pp. 940-944, 1991.
"Haemoglobin in Gut Lavage Fluid as a Measure of Gastrointestinal Blood Loss," The Lancet, vol. 340, pp. 1381-1382, Dec. 5, 1992.
Fielder Paul N.
Levine Robert A.
Wardlaw Stephen C.
Freed Rachel Heather
Housel James C.
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