Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-02-06
2010-12-28
Strzelecka, Teresa E (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
07858309
ABSTRACT:
Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.
REFERENCES:
Hebb, A. et al., “Apoptosis-related genes as markers of disease subtypes and treatment response in multiple sclerosis”, Can. J. Neurol. Sci., Suppl. 1, pp. S55-S56 (2005).
Sharief, M.K. et al., Upregulation of the inhibitor of apoptosis proteins in activated T lymphocytes from patients with multiple sclerosis, Journal of Neuroimmunology, 199 (2001), 350-357.
Semra, Y.K. et al, Disease activity in multiple sclerosis correlates with T lymphocyte expression of the inhibitor of apoptosis proteins, Journal of Neuroimmunology, 122 (2002), 159-166.
Chawla-Sarkar, Mamta et al., Preferential Induction of apoptosis by interferon (IFN)-β compared with IFN-α2 : Correlation with TRAIL/Apo2L Induction in melanoma cell lines, Clinical Cancer Research, vol. 7, 1821-1831, Jun. 2001.
Leaman, Douglas W. et al., Identification of X-linked inhibitor of apoptosis-associated Factor-1 as an Interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis, The Journal of Biological Chemistry, vol. 277, No. 32, Aug. 9, 2002, 28504-28511.
Sharief, M.K. et al., Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-β therapy, Journal of neuroimmunology 129, (2002), 224-231.
Sharief, M.K. et al., Upregulated survivin expression in activated T lymphocytes correlates with disease activity in multiple sclerosis, European Journal of Neurology, 2002, 9, 503-510.
Bhan Virender
Gillard John W.
Hebb Andrea
Holcik Martin
Korneluk Robert G.
Dianovix, Inc.
Fasken Martineau DuMoulin LLP
Strzelecka Teresa E
Swain Philip
LandOfFree
Method for differentiating between multiple sclerosis subtypes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for differentiating between multiple sclerosis subtypes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for differentiating between multiple sclerosis subtypes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4235971