Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1989-02-21
1991-10-22
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 436806, 514 23, G01N 3100, G01N 2400
Patent
active
050594150
ABSTRACT:
An improved method for diagnosing and characterizing brain lesions is described which first involves chemically modifying the blood-brain barrier (BBB) in order to increase BBB permeability. Thereafter, a chemical agent (e.g. monoclonal antibody) is introduced which binds directly, specifically and exclusively to brain lesons. The chemical has a label attached thereto (e.g. gadolinium-DTPA). The chemical agent and label localize in regions of brain lesion proliferation. Thereafter, the brain is quantitatively analyzed to determine the amount of labeling agent present, preferably using magnetic resonance imaging techniques. This procedure enables the accurate analysis of brain lesions, and represents an advance in the art of diagnostic imaging.
REFERENCES:
patent: 4331647 (1982-05-01), Goldenberg
patent: 4479932 (1984-10-01), Bodor
patent: 4540564 (1985-09-01), Bodor
patent: 4735210 (1988-05-01), Goldenberg
patent: 4764598 (1988-08-01), Srivastava
patent: 4866042 (1989-10-01), Neuwelt
patent: 4900539 (1990-02-01), Goodman et al.
Korguth, S. E. et al., J. Neurosurgery 66:698-906 (1987).
Barranger, J. A. et al., Modification of the Blood Brain Barrier: Increased Concentration & Fate of the Enzymes Entering the Brain Med. Sci 76(1):481-485 (1979).
Blasberg, R. G. et al., Regional Localization of a Glioma Associated Antigen Defined by Monoclonal Antibody, 81C6 in vivo Cancer Research 47:4432-4443 (1987).
Krejcarek, G. E. et al., Covalent Attachment of Chelating Groups to Macromolecules 77(2):581-585 (1977).
Hiesiger, E. M. et al., Opening the Blood Brain & Blood Tumor Barriers in Experimental Rat Brain Tumors Annimals of Neurology 19:50-59 (1986).
Hollinden Gary E.
Hollrah Glennon H.
The State of Oregon Acting By and Through the Oregon State Board
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