Chemistry: analytical and immunological testing – Clotting or clotting factor level tests
Patent
1994-11-14
1998-01-06
Warden, Jill
Chemistry: analytical and immunological testing
Clotting or clotting factor level tests
436 86, 435 13, 435810, 422 61, G01N 3386
Patent
active
057053952
ABSTRACT:
The present invention provides an in vitro method useful for the diagnosis of a thrombotic disorder in a subject, having or at risk of having the disorder. Specifically, the disorder exemplified herein is associated with APC resistant Factor V and Va. The clotting time of a test sample is analyzed in the presence and absence of APC and compared with a standard reference sample in order to diagnose the subject.
REFERENCES:
patent: 5051357 (1991-09-01), Hassouna
patent: 5169786 (1992-12-01), Carroll et al.
patent: 5443960 (1995-08-01), Dahlback
patent: 5472852 (1995-12-01), Smirnov et al.
Legnani et al. The Lancet, vol. 343, Feb. 26, 1994, pp. 541-542.
Zoller et al. The Lancet, vol. 343, Jun. 18, 1994, pp. 1536-1538.
Greengard et al. The New England Journal of Medicine, vol. 331, No. 23, Dec. 8, 1994, pp. 1559-1562.
Le et al. Blood, vol. 85, No. 7, Apr. 1, 1995, pp. 1704-1711.
Bertha et al. Nature, vol. 369, May 5, 1994, pp. 64-67.
Voorberg et al. The Lancet, vol. 343, Jun. 18, 1994, pp. 1535-1536.
Blood Coagulation Factor Va Abnormality Associated With Resistance to Activated Protein C in Venous Thrombophilia Sun, et al., Blood, No. 11, 83:3120-3125, Jun. 1, 1994.
Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of cofactor . . . Dahlback, et al., Proc. Natl. Acad. Sci. USA, 90:1004-1008, Feb. 1993.
Multicenter Evaluation of a Kit for Activated Protein C Resistance on Various Coagulation Instruments Using Plasmas from Healthy Individuals Rosen, et al., Thrombosis and Haemostasis, No. 2, 72:255-260, 1994.
Diagnosis of activated protein C resistatnce (factor V Leiden).
Baker, et al., The Lancet, 44:162, Oct. 22, 1994.
Modified Test for activated protein C resistance.
Noel W. Preston, The Lancet, 44:162-163, Oct. 22, 1994.
Coatest--APC Resistance.
Chromogenix AB, Sweden.
Griffin John H.
Le Dzung T.
Rapaport Samuel I.
The Regents of the University of California
The Scripps Research Institute
Wallenhorst Maureen M.
Warden Jill
LandOfFree
Method for diagnosis of thrombotic disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for diagnosis of thrombotic disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for diagnosis of thrombotic disorders will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2328482