Method for diagnosis of rheumatoid arthritis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 4, 436 86, 436501, 436504, 436506, 436509, 436518, 436530, 436536, 436542, 436548, 436804, 436811, G01N 3353

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048638501

ABSTRACT:
A substantially pure rheumatoid arthritis specific protein (RASP) and an antibody against the rheumatoid arthritis specific protein (anti-RASP antibody) are disclosed. The RASP is found specifically in the serum or plasma of a patient suffering from rheumatoid arthritis, and may be detected using an anti-RASP antibody easily and effectively. Therefore, the anti-RASP antibody of the present invention is useful for the diagnosis of rheumatoid arthritis by the criterion of the presence of RASP.

REFERENCES:
patent: 4420461 (1983-12-01), Reckel et al.
patent: 4544640 (1985-10-01), Soma et al.
Fong et al., J. Immunol., vol. 131, No. 2, pp. 719.varies.723 (1983).
T. Kanamono et al., "An Experience of Plasma Exchange for Patients with Rheumatoid Arthritis", pp. 280-286 (Ref. 1).
T. Kanamono et al., "Analysis of Plasma Filtrated Protein and Finding of New Rheumatoid Arthritis Specific Protein", p. 20, (Ref. 2).

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