Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-06-22
2008-10-14
Landsman, Robert (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S387100
Reexamination Certificate
active
07435551
ABSTRACT:
This invention provides a method for diagnosing geriatric diseases associated with insulin resistance, such as type II diabetes, at an early stage and a method for monitoring the therapeutic effects of agents for type II diabetes by quantitatively assaying GBP28 with the use of a monoclonal antibody that can assay adiponectin (GBP28) in a sample.
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Weyer et al., “Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia”,The Journal of Clinical Endocrinology&Metabolism, vol. 86, No. 5, pp. 1930-1935, 2001.
Hotta et al., “Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys”,Diabetes, vol. 50, pp. 1126-1133, 2001.
Yang et al., “Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin”,The Journal of Clinical Endocrinology&Metabolism, vol. 86, No. 8, pp. 3815-3819, 2001.
Yukio Arita et al., “Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity,”Biochem. Biophys. Res. Commun., vol. 257, No. 1, pp. 79-83 (1999).
Yasuko Nakano et al., “Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma,”J. Biochem., vol. 120, No. 4, pp. 803-812 (1996).
Kikuko Hotta et al., “Plasma Concentrations of a Novel Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients,”Arteriscler. Thromb. Vasc. Biol., No. 20, p. 1595-1599 (2000).
Hirose Hiroshi
Matsubara Koichi
Nakano Yasuko
Tomita Motowo
Chandra Gyan
Fujirebio Inc.
Landsman Robert
Wenderoth , Lind & Ponack, L.L.P.
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