Method for diagnosing the presence or absence of oncological dis

Chemistry: analytical and immunological testing – Cancer

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436 63, 436164, 436909, 73 6148, G01N 3349

Patent

active

055082017

ABSTRACT:
The invention pertains to a method for diagnosing oncological diseases wherein an effective small amount of blood is obtained, such as from a finger, and a solution containing blood plasma or serum is exposed to laser radiation and the values of one or more parameters are determined upon measurements at molecular level. Said parameters are then compared with analogous measured or established parameters of a reference solution to determine whether there are significant variations or similarities which indicate the absence or presence of oncological diseases or a predisposition to same. In a preferred embodiment of the invention, blood plasma or serum is diluted in water up to 25% of the volume and the solution is then exposed to laser radiation in the standard mode. Measurements and determinations are then made of the coefficient of Rayleigh light scattering "R" in the solution and other indicative parameters such as the effective mass "M" and a parameter of molecular interaction "B" of scattered particles in the solution. The values of R, M and B are then compared with respective reference indicative parameters R.sub.ref, M.sub.ref and B.sub.ref of a calculated or established reference standard or a reference solution, such as one obtained from the blood serum of healthy individuals. If R/R.sub.ref >2, M>M.sub.ref and B<B.sub.ref, then an oncological disease is diagnosed.

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patent: 4767717 (1988-08-01), Baisden
patent: 4912050 (1990-03-01), Fossel
patent: 4918021 (1990-04-01), Fossel

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