Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2010-10-24
2011-11-29
Babic, Christopher M. (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023740, C435S975000
Reexamination Certificate
active
08067568
ABSTRACT:
A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons1, 2a, 2b, 3, 4, 5, 6, 7, and8by a universal multiplex PCR using the nucleotide as a template and the primers to obtain fragments of the SMN exons1, 2a, 2b, 3, 4, 5, 6, 7, and8, labeling the fragments of the SMN exons1, 2a, 2b, 3, 4, 5, 6, 7, and8by a fluorescent primer to obtain fluorescence-labeled exon fragments, and analyzing the fluorescence-labeled exon fragments by a capillary electrophoresis. If the SMN1/SMN2 ratios in exon7and8are different, it indicates that the subject is susceptible to spinal muscular atrophy. Additionally, if the peak of certain exon fragment appears crossed, it indicates an intragenic mutation in the exon.
Chang Jan-Gowth
Jong Yuh-Jyh
Wang Chun-Chiu
Wu Shou-Mei
Babic Christopher M.
David Pai Chao-Chang
Kaohsiung Medical University
Pai Patent & Trademark Law Firm
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