Method for diagnosing rheumatoid arthritis via assaying...

Details Method for diagnosing rheumatoid arthritis via assaying... Method for diagnosing rheumatoid arthritis via assaying...

2006-12-05

2011-11-29

Yu, Melanie J (Department: 1641)

Chemistry: analytical and immunological testing

Test for named disease, body condition or organ function

C435S007100, C435S007920, C436S063000

Reexamination Certificate

active

08067248

ABSTRACT:
The invention relates to methods for diagnosing rheumatoid arthritis by assaying for Fibroblast Activation Protein Alpha expression in rheumatoid, myofibroblast like synoviocytes. Therapeutic aspects are also a part of the invention.

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Sedo et al., Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis?, Arthritis Research & Therapy 2005, 7 pages 253-269.
Garin-Chesa et al., “Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers,” Proc. Natl. Acad. Sci. USA, vol. 87, pp. 7235-7239 (Sep. 1990).
Scanlan, et al., “Molecular cloning of fibroblast activation protein a, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers,” Proc. Natl. Acad. Sci. USA, vol. 91, pp. 5657-5661 (Jun. 1994).
Kelly, “Fibroblast activation protein-a and dipeptidyl peptidase IV (CD26): Cell-surface protease that activate cell signaling and are potential targets for cancer therapy,” Drug Resistance Updates, vol. 8, pp. 51-58 (2005).

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