Chemistry: analytical and immunological testing – Including chromatography
Patent
1993-08-19
1996-01-16
Housel, James C.
Chemistry: analytical and immunological testing
Including chromatography
210656, 210660, 436 63, 436174, G01N 3002
Patent
active
054847338
ABSTRACT:
The present invention relates to a rapid, simple and reliable method and a device for diagnosing rheumatism under no influence of diet. The method for diagnosing rheumatism includes injecting the urine sample from a suspected case of rheumatism into one end of a solid phase packed in a separation column 3, thereafter eluting a phosphate buffer as an eluent to separate the analytes contained in the urine sample, subsequently detecting the individual separated analytes with a detector 4 to confirm that a predetermined chromatogram is demonstrated by liquid chromatography, the chromatogram developing a higher chromato-peak of the rheumatism-specific component contained in the urine of the patient compared with a chromato-peak of non-rheumatic individual, and establishing the diagnosis of rheumatism on the basis of the presence of the higher peak, wherein a negative/positive charged micellar stationary phase is employed as the stationary phase, including a support carrier and a zwitterionic layer formed by directly or indirectly coating CHAPS and/or CHAPSO micelle on the surface of the support carrier.
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Housel James C.
Inoue Soichi
Ludlow Jan M.
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