Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-06-27
2006-06-27
O'Hara, Eileen (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C435S007100
Reexamination Certificate
active
07067634
ABSTRACT:
This invention provides a method for diagnosing geriatric diseases associated with insulin resistance, such as type II diabetes, at an early stage and a method for monitoring the therapeutic effects of agents for type II diabetes by quantitatively assaying GBP28 with the use of a monoclonal antibody that can assay adiponectin (GBP28) in a sample.
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patent: 01/32868 (2001-05-01), None
Kikuko Hotta et al.,Arterioscler. Thromb. Vasc. Biol.,No. 20, p. 1595-1599 (2000).
Arita et al., “Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity”,Biochem. Biophys. Res. Commun.,vol. 257, No. 1, 1999, pp. 79-83.
Nakano et al., “Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma”,J. Biochem.,vol. 120, No. 4, 1996, pp. 803-812.
Weyer et al., “Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia”,The Journal of Clinical Endocrinology&Metabolism,vol. 86, No. 5, pp. 1930-1935, 2001.
Hotta et al., “Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitvity During the Progression to Type 2 Diabetes in Rhesus Monkeys”,Diabetes,vol. 50, pp. 1126-1133, 2001.
Yang et al., “Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Infammatory Protein, Adiponectin”,The Journal of Clinical Endocrinology&Metabolism, vol. 86, No. 8, pp. 3815-3819, 2001.
HIrose Hiroshi
Matsubara Koichi
Nakano Yasuko
Tomita Motowo
Chandra Gyan
O'Hara Eileen
Rebio Gen, Inc.
Wenderoth , Lind & Ponack, L.L.P.
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