Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-11-21
1993-12-14
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 79, 435 792, 435 793, 435 794, 435 795, 435 29, 436514, 436515, 436516, 436518, 436548, C12Q 100, C12Q 102
Patent
active
052701689
ABSTRACT:
The present invention provides methods for the diagnosis of non-healing ulcers in humans. Provided are methods for detecting the presence of non-healing ulcers by assaying for certain cell adhesion-related proteins or their degradation products in ulcer exudate. The methods of the present invention are useful as an initial, quick and inexpensive screening process for a condition which is often misdiagnosed. It has been discovered that in non-healing ulcers there appear to be proteases which degrade cell adhesion-related proteins, e.g., fibronectin and vitronectin. Protein separation techniques, such as electrophoresis, may be used in combination with immunoassay techniques to isolate and identify these degradation products, as well as the cell adhesion-related proteins themselves.
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Board of Regents , The University of Texas System
Rosen Sam
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