Surgery – Diagnostic testing – Cardiovascular
Reexamination Certificate
2006-01-31
2006-01-31
Getzow, Scott M. (Department: 3762)
Surgery
Diagnostic testing
Cardiovascular
Reexamination Certificate
active
06993377
ABSTRACT:
A method of analyzing electrocardiogram (EKG) data for use in the diagnosis of heart disease, prognosis of cardiac conditions, and the monitoring of heart disease therapies is disclosed. The method utilizes a wavelet-based multifractal analysis with one or more of (1) a discrete wavelet smoothing step to remove the effects of abnormal beats; (2) “Levy flight” analysis to detect the frequency of abnormal beats known to adversely affect the multifractal (MF) analysis; and (3) MF alpha analysis, a multifractal extension of monofractal short term (ST) alpha analysis. The invention further comprises an EKG test battery comprising Levy flight anomalous beat/beat cluster screening, followed by (ST) MF alpha analysis and MF Holder analysis (when validated by the Levy flight analysis). The wavelet smoothing step can also be used to classify human EKGs by observing the effect of sequential smoothing on the MF Holder coefficient. Alternative choices to the wavelet smoothing approach to removal of abnormal beat effects include probability distribution function analysis to determine the MF Holder coefficient directly, abnormal beat ridge skeleton removal to remove the offending beats based on a direct multifractal spectrum calculation, and the calculation of various types of entropy coefficients for the EKG time series.
REFERENCES:
patent: 5471991 (1995-12-01), Shinnar
“Predicting Survival in Heart Failure Case and Control Subjects by Use of Fully Automated Methods for Deriving Nonlinear and Conventional Indices of Heart Rate Dynamics;” Kalon K.L. Ho, MD, et al;American Heart Associaton, Inc., 1997; 96:842-848.
Abstract from PubMed: “Dynamic Analysis of Heart Rate May Predict Subsequent Ventricular Tachycardia after Myocardial Infarction;” Makikallio TH, et al;American Journal of Cardiology, Sep. 15, 1997; 80(6): 779-83.
Abstract from PubMed: “Heart Rate Dynamics in Patients with Stable Angina Pectoris and utility of Fractal and Complexity Measures;” Makikallio TH, et al;American Journal of Cardiology, Jan. 1, 1998; 81 (1):27-31.
“Fractal Correlation Properties of R-R Interval Dynamics and Mortality in Patients with Depressed Left Ventricular Function after an Acute Myocardial Infarction;” Heikki V. Huikuri, MD, et al;Circulation, 2000;101:47-53.
Abstract from PubMed: “Fractal Analysis of Heart Rate Dynamics as a Predictor of Mortality in Patients with Depressed Left Ventricular Function after Acute Myocardial Infarction. TRACE Investigators. TRAndolapril Cardiac Evaluation;” Makkikallio TH, et al;American Journal of Cardiology, Mar. 15, 1999; 83(6):836-9.
Abstract from PubMed: “Fractal Analysis and Time-and Frequency-Domain Measures of Heart Rate Variability as Predictors of Mortality in Patients with Heart Failure;” Makikallio TH, et al;American Journal of Cardiology, Jan. 15, 2001; 87(2): 178-82.
“Scale Specific and Scale Independent Measures of Heart Rate Variability as Risk Indicators;” Y. Ashkenazy, et al;Los Alamos arXiv:physics/9909029, Sep. 17, 1999.
Abstract from PubMed: “Reversal of Deteriorated Fractal Behavior of Heart Rate Variability by Beta-Blocker Therapy in Patients with Advanced Congestive Heart Failure;” Lin LY, et al;Journal of Cardiovascular Electrophysiol, Jan. 2001; 12(1):26-32.
“Altered Complexity and Correlation Properties of R-R Interval Dynamics Before the Spontaneous Onset of Paroxysmal Atrial Fibrillation;” Saila Vikman, MD, et al.;CirculationNov. 16, 1999; 2079-84.
“Multifractality in Human Heartbeat Dynamics;” Plamen Ch. Ivanov, et al;Nature, vol. 399, Jun. 3, 1999, 461-65.
“Behavioral-Independent Features of Complex Heartbeat Dynamics;” Luis A. Nunes Amaral, et al;Los Alamos arXiv:cond-mat/0106508, vol. 1, Jun. 25, 2001.
Behavioral-Independent Features of Complex Heartbeat Dynamics; Luis A. Nunes Amaral, et al;Physical Review Letters; vol. 86, No. 26; Jun. 25, 2001; 6026-29.
“The Multifractal Formalism Revisted with Wavelets;” J.F. Muzy, et al.;International Journal of Bifurcation and Chaos, vol. 4, No. 2 (1994) 245-302.
“A Multifractal Wavelet Model with Application to Network Traffic,” Rudolf H. Riedi, et al;IEEE Transactions on Information Theory, Apr. 1999.
“Singularity Detection and Processing with Wavelets;” Stephane Mallat, et al;IEEE Transactions on Information Theory, vol. 38, No. 2, Mar. 1992, 617-43.
“Characterization of Self-Similar Multifractals with Wavelet Maxima;” Wen-Liang Hwang, et al;Technical Report641, Jul. 1993.
“A Wavelet-Based Method for Multifractal Image Analysis;” A. Arneodo, et al;European Physical Journal B, 15, 567-600 (2000), 567
“Dynamic Behavior and Autonomic Regulation of Ectopic Atrial Pacemakers;” Heikki V. Huikuri, MD, et al;Circulation, Sep. 28, 1999, 1416-1422.
“Effects of Exercise and Passive Head-up Tilt on Fractal and Complexity Properties of Heart Rate Dynamics;” Mikko P. Tulppo, et al;American Journal Physiol Heart Circ Physiol280: H1081-H1087, 2001.
Abstract: “Chaotic Advection in a Two-Dimensional Flow: Levy Flights and Anomalous Diffusion;” T.H. Solomon, et al;Physica D76 70-84 (1994).
Abstract: “Long-Range Anticorrelations and Non-Gaussian Behavior of the Heartbeat;” C.-I. Peng, J.;Physical Review Letters, vol. 70, No. 9, 1343-46 (Mar. 1, 1993).
Abstract: “Wavelet Methods for Time Series Analysis;” Donald B. Percival, et al;Cambridge Series in Statistical and Probabilistic Mathematics, Oct. 5, 2000.
“A Wavelet-Based Method for Multifractal Image Analysis;” N. Decoster, et al;The European Physical Journal B15, 739-764 (2000).
“A Wavelet-Based Method for Multifractal Analysis;” S.G. Roux, et al;The European Physical Journal B 15, 765-786 (2000).
“Direct Multifractal Spectrum Calculation from the Wavelet Transform;” Z.R. Struzik;Information Systems(INS); R9914; Oct. 31, 1999; 1-10.
“Dimension and Product Structure of Hyperbolic Measures;” Luis Barreira, et al.;Ann. of Math.(2) 149 (1999), 755-783.
“Variational Principles and Mixed Multifractal Spectra;” L. Barreira;Trans. Amer. Math. Soc.353 (2001), 3919-3944.
“The Rate of Entropy Increase at the Edge of Chaos;” Vito Latora;Physics LettersA 273 (2000) 97-103.
“On a General Concept of Multifractality: Multifractal Spectra for Dimensions, Entropies, and Lyapunov Exponents, Multifractal Rigidity;” Luis Barreira, et al;Chaos 7(1997), No. 1, 27-38.
Abstract: “Dimension Theory in Dynamical Systems;” Pesin, Yakov B.;Contemporary Views and Applications, xii, 305 p. 1997 Series (CLM).
“Characteristic Distributions of Finite-Time Lyapunov Exponents;” Awadhesh Prasad, et al;Physical Review E, vol. 60, No. 3, Sep. 199, 2761-2766.
Generalization of the Kolmogorov-Sinai Entropy: Logistic-and Periodic-Like Dissipative Maps at the Chaos Threshold;: Ugur Tirnakli et al;Los Alamos arXiv.cond-mat/0005210, vol. 1, May 12, 2000, 1-12.
“Application of the Wavelet Transform in the laminar Turbulent Transition for a Flow in a Mixed Convection Phenomenon;” C. Abid, et al;The European Physical Journal B13, 707-714 (2000).
“A Multifractal Random Walk;” E. Bacry et al;Los Alamos arXiv:cond-mat/0005405; May 24, 2000.
“Singularity Spectra of Rough Growing Surfaces from Wavelet Analysis;” M. Ahr, et al;arXiv:cond-mat/9912437, vol. 2; Apr. 3, 2000.
Modeling Heart Rate Variability by Stochastic Feedback;: Luis A. Nunes Amaral;Computer Physics Communications, 121-122 (1999) 126-128.
“Scale-Independent Measures and Pathologic Cardiac Dynamics;” Luis A. Nunes Amaral, et al;Physical Review Letters, vol. 81, No. 11, Sep. 14, 1998, 2388-2391.
“Fractal Analysis for Social Systems;” C.M. Arizmendi:Los Alamos arXiv:adap-org/9910001; Oct. 14, 1999.
“Oscillating Singularities on Cantor Sets; A grand-cano
Flick James T.
Joseph Jacob
Dougherty J. Charles
Getzow Scott M.
The Board of Trustees of the University of Arkansas
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