Method for diagnosing diabetic retinopathy by single...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Reexamination Certificate

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07897739

ABSTRACT:
Disclosed is a method for diagnosing diabetic retinopathy by a single nucleotide polymorphism of VEGF and its receptor.

REFERENCES:
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Claffey, Kevin P., Shih, Shu-Ching, Mullen, Andrew, Dziennis Suzan, Cusick, Jennifer L., Abrams, Kristin R., Lee, Sam W., and Detmar, Michael; “Identification of a Human VPF/VEGF 3′ Untranslated Region Mediating Hypoxia-induced mRNA Stability”; Molecular Biology of the Cell; vol. 9, No. 2, Feb. 1998; pp. 469-481.
Qaum, Tamin, Xu, Qingwen, Joussen, Antonia M., Clemens, Mark W., Qin, Wenying, Miyamoto, Kazuaki, Hassessian, Haroutioun, Wiegand, Stanley J., Rudge, John, Yancopoulos, George D., and Adamis, Anthony P.; “VEGF-initiated Blood-Retinal Barrier Breakdown in Early Diabetes”; Investigative Ophthalmology & Visual Science; vol. 42, No. 10, Sep. 2001; pp. 2408-2413.
Koga, Kaori, Osuga, Yutaka, Yoshino, Osamu, Hirota, Yasushi, Ruimeng, Xie, Hirata, Tetsuya, Takeda, Satoru, Yano, Tetsu, Tsutsumi, Osamu, Taketani, Yuji; “Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia”; The Journal of Clinical Endocrinology & Metabolism; vol. 88, No. 5, May 2003; pp. 2348-2351.
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Awata et al.,Brief Genetics Report“A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabets”,Diabetes, vol. 51, May 2002.
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NCBI Assay ID: ss4251017, (reISNP ID: rs3025039), Entry date: Nov. 6, 2001 (7 pgs.).
NCBI Assay ID: ss4251018, (reISNP ID: rs3025040), Entry date: Nov. 6, 2001 (7pgs.).
NCBI Assay ID: ss4999276, (reISNP ID: rs3812867), Aug. 12, 2002 (1 pg.).
PCT International Search Report, based on International Application No. PCT/KR2005/001464, date of mailing of the International Search Report, Feb. 15, 2006 (1 pg.).

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