Method for diagnosing diabetes mellitus and device therefor

Details Method for diagnosing diabetes mellitus and device therefor Method for diagnosing diabetes mellitus and device therefor

1993-08-17

1996-03-19

Housel, James C.

Chemistry: analytical and immunological testing

Including chromatography

73 6153, 2101982, 210656, 210660, 436173, G01N 3002

Patent

active

055003745

ABSTRACT:
A rapid, simple and reliable method and device for diagnosing diabetes mellitus under no influence of diet. The method for diagnosing diabetes mellitus involves injecting a saliva sample from a patient suspected of having diabetes mellitus into a stationary phase in a separation column, thereafter eluting a phosphate buffer as an eluent to separate analytes contained in the saliva sample, subsequently detecting the individual separated analytes with a UV detector and electrostatic ion chromatography to produce a chromatogram, and then diagnosing diabetes mellitus based on the presence or absence of a chromato-peak of the diabetes mellitus-specific component. A zwitterionic stationary phase is employed as the stationary phase and contains a support carrier and a zwitterionic charged layer formed by coating a compound having an ammonium salt portion, a sulfonate ion portion or carboxylate ion portion on the surface of the support carrier.

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