Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2007-10-09
2007-10-09
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007100, C435S006120, C435S130000, C435S325000, C514S002600, C530S388260
Reexamination Certificate
active
10960652
ABSTRACT:
Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating protein, and methods of preventing or ameliorating diabetes by administering a compound capable of the expression of a diabetes-mediating protein.
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Mose Larsen P. et al. “Proteome analysis of interleukin-1beta-induced changes in protein expression in rat islets of Langerhans.” DIABETES, vol. 50, May 2001 pp. 1056-1063.
John N.E. et al. “Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel eletrophoresis in neonatal rat islets of Langerhans.” DIABETES, vol. 49, Nov. 2000, pp. 1819-1829.
Andersen H.U. et al. “Interleukin-1beta induced changes in the protein expression of rat islets: a computerized database.” ELECTROPHORESIS, vol. 18, 1997, pp. 2091-2103.
Christensen U.B. et al. “Islet protein expression changes during diabetes development in islet syngrafts in BB-DP islet allografts.” AUTIMMUNITY, vol. 32, 2000, pp. 1-15.
Fey Stephen J.
Karlsen Allan E.
Larsen Peter Mose
Nerup Jorn
Sparre Thomas
Chowdhury Iqbal
Pride Proteomics A/S
Prouty Rebecca E.
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