Method for diagnosing autoimmune diseases

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 4, 435 721, 435 723, 435 724, 436 63, 436 64, 436805, C12Q 102, C12Q 100, G01N 3353, G01N 3348

Patent

active

058467580

ABSTRACT:
A method for diagnosing autoimmune disease in mammals, including humans, is described. A blood sample is collected from a subject, and mononuclear white blood cells separated therefrom. The mononuclear cells then are cultured in vitro. Patients with autoimmune disease develop characteristic white cell aggregates with autophagocytosis in the culture. Mononuclear cells from normal patients do not exhibit this cell aggregation with autophagocytosis.

REFERENCES:
patent: 4420461 (1983-12-01), Reckel et al.
patent: 4420558 (1983-12-01), De Mey et al.
patent: 4595654 (1986-06-01), Reckel et al.
patent: 4614722 (1986-09-01), Pasula
patent: 4659659 (1987-04-01), Dwek et al.
patent: 4743540 (1988-05-01), Ralph et al.
patent: 4748110 (1988-05-01), Paul
patent: 5147785 (1992-09-01), Pasula
patent: 5162990 (1992-11-01), Odeyale et al.
patent: 5192537 (1993-03-01), Osband
patent: 5298396 (1994-03-01), Kotzin et al.
patent: 5426028 (1995-06-01), Levy et al.
patent: 5445939 (1995-08-01), Anderson
patent: 5464833 (1995-11-01), Nakai et al.
McElrath et al, Proc. Natl. Acad. Sci., USA; vol. 86, pp. 675-679, Jan. 1989.
Jones, Carolyn J.P. and Jayson, Malcolm I., Chloroquine: its effect on leucocyte auto- and heterophagocytosis, Annals of the Rheumatic Diseases, Apr. 1984, vol. 43, No. 2, pp. 205-212.
Ericsson, Jan L.E., Holm, Goran, and Biberfeld, Peter, Increased Autophagocytosis in Renal Proximal Tubules during Experimental "Autoimmune" Nephrosis, Virchows Archiv Abteilung B Zellpathologie-Cell Pathology, (1969) vol. 2, pp. 74-84. Month not available.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for diagnosing autoimmune diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for diagnosing autoimmune diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for diagnosing autoimmune diseases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-176080

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.