Method for diagnosing alzheimer's disease

Details Method for diagnosing alzheimer's disease Method for diagnosing alzheimer's disease

1999-03-04

2000-07-11

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 4, 424529, 424532, C12Q 156, C12Q 100

Patent

active

060871180

ABSTRACT:
A method is provided for diagnosing Alzheimer's disease using human blood platelets wherein the presence or absence of functioning calcium-dependent potassium channels in blood platelets are determined by employing potassium channel blockers such as apamin or charybdotoxin, the absence of functioning calcium-dependent potassium channels indicating a positive diagnosis for Alzheimer's disease.

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Etcheberrigaray, R. et al, Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer's disease, Proc. Natl. Acad. Sci., USA, 90, 8209-8213 (1993).
Etcheberrigaray, R. et al, Soluble .beta.-amyloid induction of Alzheimer's phenotype for human fibroblast K.sup.30 channel, Science, 264, 276-276 (1994).

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