Method for diagnosing a patient to determine whether the patient

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A61B 50476

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051761459

ABSTRACT:
A patient is diagnosed to determine whether the patient has a limbic system dysrhythmia and capable of being treated by administration of an anticonvulsant medication by determining whether the patient exhibits symptoms in at least four groups out of twelve defined groups of symptoms. In addition, an electroencephalogram is studied for any focal abnormalities in the temporal parietal areas and, if there are none, the patient is administered a local anaesthetic, procaine, and the electroencephalogram is evaluated for omega band activity (30-50 Hz). A patient exhibiting either focal abnormalities in the temporal-parietal areas on the standard electroencephalogram or, after procaine, exhibiting omega band activity of at least about three times the baseline voltage above normal and exhibiting symptoms in at least four groups of the twelve groups of defined symptoms is diagnosed as having Limbic System Dysrhythmia and being capable of treatment by administering an anticonvulsant medication.

REFERENCES:
patent: 4533346 (1985-08-01), Cosgrove et al.
patent: 4550736 (1985-11-01), Broughton et al.
Adamec et al., "Basic Science and Clinical Aspects of Procaine HCl As a Limbic System Excitant," Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 1985, vol. 9, pp. 109-119, Permagon Press Limited.
Kellner et al., "Intravenous Procaine As a Probe of Limbic System Activity in Psychiatric Patients and Normal Controls," Biol. Psychiatry, 1987, vol. 22, pp. 1107-1126.
Adamec et al., "The Effects of Procaine HCl on Population Cellular and Evoked Response Activity Within the Limbic System of the Cat. Evidence for Differential Excitatory Action of Procaine in a Variety of Limbic Circuits," Prog. Neuropsychopharmacol. Biol. Psychiatry, 1987, vol. 11 (4), pp. 345-364.
Adamec et al., "Power Spectral Analysis of EEG Drug Response in the Kindled Rat Brain," Electroencephalogr. Clin. Neurophysiol., 1981, vol. 52(5), pp. 451-460.
Stark et al., "Analysis of Facial Displays and Verbal Report to Assess Subjective State in the Non-Invasive Detection of Limbic System Activation by Procaine Hydrochloride," Behav. Brain Res., 1982, Jan., vol. 4 (1), pp. 77-94.
Kling et al., "Neuroendocrine Effects of Limbic Activation by Electrical, Spontaneous and Pharmacological Modes: Relevance to the Pathophysiology of Effective Disregulation in Psychiatric Disorders," Prog. Neuropsychopharmacol. Biol. Psychiatry, 1987, vol. 11 (4), pp. 459-481.
Kellner, "Intravenous Procaine As a Probe of Limbic Systems Activity in Psychiatric Patients and Normal Controls," Biol. Psychiatry, 1987, Sep., vol. 22 (9), pp. 1107-1126.
Pollock, "The Kindling Phenomenon and a Clinical Application: The Procaine Test," The Psychiatric Journal of the University of Ottawa, vol. 10, No. 4, pp. 185-191, Dec. 1985.
Himmelhoch, "Cerebral Dysrhythmia, Substance Abuse, and the Nature of Secondary Affective Illness," Neuropsychiatry of Mood Disorders, Psychiatric Annals, 17 (11), Nov. 1987, pp. 710-727.

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