Method for determining von Willebrand factor

Chemistry: analytical and immunological testing – Sedimentation rate or hematocrit

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436 45, 436 69, 356 39, 435 13, G01N 2182

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active

052310337

ABSTRACT:
The invention relates to a method for the functional determination of von Willebrand factor by determination of the sedimentation rate of platelets in the presence of ristocetin during centrifugation.

REFERENCES:
patent: 4640896 (1987-02-01), Farrell et al.
patent: 4777141 (1988-10-01), Calzi et al.
patent: 4936674 (1990-06-01), Ikeda et al.
Ruggeri et al., "von Willebrand Factor and von Willebrand Disease", Blood, vol. 70, No. 4, (Oct.), 1987, pp. 895-904.
Macfarlane et al., "A Method for Assaying von Willebrand Factor (Ristocetin Cofactor)", Thrombos, Diathes, heamorrh, (Stuttg.) 1975, 34, 306.
Bowie, D. M., "von Willebrand's Disease, Clinical Picture, Diagnosis, and Treatment", Clinics in Laboratory Medicine, vol. 4, No. 2, Jun. 1984, pp. 303-317.
Goodall et al., "An Immunoradiometric Assay For Human Factor VIII/von Willebrand Factor (VII:vWF) Using a Monoclonal Antibody That Defines A Function Epitope", British Journal of Haematology, 1985, 59, 565-577.
Y. Sufan et al., "An Immunoradiometric Assay for Factor VII Related Antigen (VIIRAg) Using Two Monoclonal Antibodies--Comparison with Polyclonal Rabbit Antibodies for Use in von Willebrand's Disease Diagnosis", Thromb. Haemost., vol. 52, (1984), pp. 250-252.

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