Method for determining tyrosine kinase in a sample

Details Method for determining tyrosine kinase in a sample Method for determining tyrosine kinase in a sample

1997-02-25

1998-10-13

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

3503879, 3503881, 35038825, 35038826, 35038885, 3503891, G01N 3353, G01N 33577, C07K 1618

Patent

active

058210695

ABSTRACT:
The invention relates to a method of determining the presence of a tyrosine kinase in a sample using antibodies that specifically bind to kinase active proteins. The proteins have more than one tyrosine kinase domain and no SH2 domains. Exemplary proteins are the Janus Kinases, or "JAK1" and "JAK2." Both polyclonal and monoclonal antibodies are used in the detection method.

REFERENCES:
patent: 5658791 (1997-08-01), Wilks
Hunter, Cell 50:823, 1987.

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