Method for determining therapeutic drug dosage using bioelectric

Details Method for determining therapeutic drug dosage using bioelectric Method for determining therapeutic drug dosage using bioelectric

1988-02-26

1989-11-14

Jaworski, Francis

Surgery

Truss

Pad

3644131, 604 50, A61B 505

Patent

active

048800147

ABSTRACT:
A method for determining a dosage regimen for a drug. Resistance (R) and reactance (Xc) are measured by bioelectrical impedance analysis with an impedance plethysmograph. Personal characteristics of a subject are ascertained and recorded along with the measured values of R and Xc. A technique for generating equations which relate the measured values of R and Xc and selected personal characteristics to pharmacokinetic parameters such as volume of distribution (V), elimination rate constant (K), and clearance (CL) for a particular drug are provided. These equations are used with the measured values of R and Xc and certain personal characteristics to determine predictive values for the desired pharmacokinetic parameters. These predictive values are then used to determine an appropriate drug dosage regimen for the patient.

REFERENCES:
patent: 4109645 (1978-08-01), Bacchelli
patent: 4557271 (1985-12-01), Stoller et al.
patent: 4562843 (1986-01-01), Djordjevich
patent: 4793362 (1988-12-01), Tedner
patent: 4794934 (1989-01-01), Motoyama et al.
Shizgal et al., "Total Body Potassium in Surgical Patients" Surgery, Jun. 1974.
Dahlgren et al., "Gentamicin Blood Levels etc.", AAC, Jul. 1975.
Sawchuk, "Pharmacokinetics of Dosing Regimens etc." JPB 1976, vol. 4 No. 2.
Schentag et al., "Comparative Tissue Accumulation etc." JAC, 1978, vol. 4, supp. A.
Lesar et al., "Gentamicin Dosing Errors etc.", JAMA, Sep. 10, 1982.
Kohlhepp et al., "Nephrotoxicity etc.", JID, Apr. 1984.
Matzke et al., "Gentamicin and Tobraycin etc.", DICP, Jun. 1983, vol. 17.
Lusaki et al., "Validation of tetrapolar etc.", JAP 1986, 60(4):1327-32.
Shizgal, "Body composition of patients etc." Cancer, 1985 Supp., vol. 55.
Lukaski et al., "Assessment of Fat-Free Mass etc." AJCN, Apr. 1985, vol. 41, pp. 810-817.
Freioman et al., "Rational Therapeutic Drug Monitoring," JAMA, Oct. 1986, vol. 255, No. 16.
McDougall et al., "Body Composition Measurements etc.," Surgical Forum, 1986, vol. 32.
Lukaski et al., "Theory and validation etc.," INTL Symposium, 1986, Broohven lab.
Kushner et al., "Estimation of total body water etc.," JCN, Sep. 1986.
Nyboer et al., "Nontraumatic Electrical Detection etc.", Proceedings of the VI ICEBI, pp. 381-384, 1983.
Medical & Biological Engineering & Computing; "Quantitative Interpretation of Arterial Impedance Plethysmorgraphic Signals"; M. Y. Jaffrin and C. Vanhoutte; Jan., 1979; pp. 2-10.
"Quantitative Parameters of Body Composition and Theophylline Deposition", Annals of Allergy, 1988.
"Bioelectrical Impedance (BI)-Predicted Drug Doses", B. J. Zarowitz, D. Twyman, Clinical Pharmacology and Therapeutics 1988;43:189.

Affiliated with

Also associated with

Rating

Method for determining therapeutic drug dosage using bioelectric does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for determining therapeutic drug dosage using bioelectric, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for determining therapeutic drug dosage using bioelectric will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1847520