Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-04-14
2010-11-09
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200
Reexamination Certificate
active
07829295
ABSTRACT:
The invention provides a method capable of readily discriminating pathologic conditions and judging selection of a therapeutic drug, the degree of the therapeutic effect, discontinuation of medication, etc., wherein stages quantitatively judged by digitizing substances contained in urine, which is different from conventional methods for judging stages of an ulcerative colitis and an interstitial pneumonitis which are performed by observation of mucous lesions with endoscopy requiring the skill or by analysis of histological samples collected from the living body.The method measures the value of main metabolites of prostaglandin E (PGE-MUM) concentration in urine and judges stages between the pre-remission phase of and the remission phase of ulcerative colitis.The method also measures the value of the PGE-MUM concentration in urine and judges stages between the active phase and the non-active phase of interstitial pneumonitis.
REFERENCES:
patent: 61-11664 (1986-01-01), None
patent: 2005-30852 (2005-02-01), None
Fujiwara, Mutsunori et al., “Significant Increase in Prostaglandin E-main Urinary Metabolite by Laxative Administration: Comparison with Ulcerative Colitis”, Digestion, 61, pp. 201-206, 2000.
Bippi, H. et al., “Effects of acetylsalicylic acid and paracetamol alone and in combination on prostanoid synthesis in man”, Br. J. clin. Pharmac., 29, pp. 305-310, 1990.
Fujiwara Mutsunori
Hayashi Yuzo
Okayasu Isao
Cheu Jacob
Fujirebio Inc.
Fujiwara Mutsunori
Hayashi Yuzo
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
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