Method for determining the effectiveness of stabilized...

Details Method for determining the effectiveness of stabilized... Method for determining the effectiveness of stabilized...

2011-01-25

2011-01-25

Warden, Jill (Department: 1797)

Chemistry: analytical and immunological testing

Halogen containing

C422S070000, C436S161000, C436S178000, C073S023390, C423S477000

Reexamination Certificate

active

07875460

ABSTRACT:
A method for determining the available treatment dosage of stabilized chlorine dioxide in the prevention and the treatment of plaque accumulation, volatile sulfur compound production, gingivitis and periodontitis, and for differentiating the treatment dosage from other chlorine-containing compounds that may not have such beneficial effects is disclosed. When in solution as stabilized chlorine dioxide, the presence of other ions such as chlorate and chloride may not only obscure results as to the concentration of stabilized ClO2, but also reduce the predicted effectiveness. The present invention uses validated analytical methods to predict the effectiveness of stabilized ClO2by more precisely measuring its concentration in solution. Such measurement renders precision at a level required of food-grade and pharmacy-grade chemotherapeutic agents in the oral cavity. Preferred concentrations are within the range of about 0.005 to about 2% (w/v) stabilized chlorine dioxide. The solution may be in the form of wash, rinse, soak, paste, gel, aerosol spray, or other suitable delivery system.

REFERENCES:
patent: 2451897 (1948-10-01), Woodward
patent: 2482891 (1949-09-01), Astori
patent: 3271242 (1966-09-01), McNicholas
patent: 4689215 (1987-08-01), Ratcliff
patent: 4696811 (1987-09-01), Ratcliff
patent: 4786492 (1988-11-01), Ratcliff
patent: 4788053 (1988-11-01), Ratcliff
patent: 4792442 (1988-12-01), Ratcliff
patent: 4793989 (1988-12-01), Ratcliff
patent: 4808389 (1989-02-01), Ratcliff
patent: 4818519 (1989-04-01), Ratcliff
patent: 4837009 (1989-06-01), Ractliff
patent: 4851213 (1989-07-01), Ratcliff
patent: 4855135 (1989-08-01), Ratcliff
patent: 4886657 (1989-12-01), Ratcliff
patent: 4889714 (1989-12-01), Ratcliff
patent: 4925656 (1990-05-01), Ratcliff
patent: 4975285 (1990-12-01), Ratcliff
patent: 5192691 (1993-03-01), Quinn et al.
patent: 5200171 (1993-04-01), Ratcliff
patent: 5348734 (1994-09-01), Ratcliff
patent: 5489435 (1996-02-01), Ratcliff
patent: 5618550 (1997-04-01), Ratcliff
patent: 5738840 (1998-04-01), Richter
patent: 5811115 (1998-09-01), Ratcliff
patent: 5834003 (1998-11-01), Ratcliff
patent: 5902575 (1999-05-01), Ratcliff
patent: 6017554 (2000-01-01), Ratcliff
patent: 6136348 (2000-10-01), Ratcliff
patent: 6231830 (2001-05-01), Madray
patent: 2003/0066336 (2003-04-01), Kotsuka et al.
American Dental Association, Fluoridation Facts. 2005.
Armitage GC. Clinical evaluation of periodontal disease.:Periodontal 20001995; 7:39-53.
Baehni PC, Takeuchi Y. “Anti-plaque agents in the prevention of biofilm-associated oral diseases.”Oral Diseases2003; 9 (suppl I):23-29.
Barnhart WE, et al. “Dentifrice Usage and Ingestion Among Four Age Groups.”J Dent Res1974; 53:1317-1322.
Marsh PD. Dental Plaque: biological significance of a biofilm and community life-style.J Clin Periodontal.2005; 32(Suppl. 6): 7-15.
Masschelein, WJ.Chlorine Dioxide: Chlorine and Environmental Impact of Oxychlorine Compounds.(1979) Anne Arbor: Ann Arbor Science Publishers, Inc.
Michael GE, et al. “Chlorine Dioxide Water Disinfection: A Prospective Epidemiology Study.”Arch Environ Health1981; 36:20-27.
Rose LF, Mealey BL, Genco, RJ, and Cohen DW.Periodontics: Medicine, Surgery, and Implants.(2004) St. Louis: Mosby, Inc.
Silwood CJL, Grootveld MC, Lynch E. A multifactorial investigation of the ability of oral health care products (OHCPs) to alleviate oral malodour.J Clin Periodontol.2001; 28:634-641.
United States Environmental Protection Agency, Alternative Disinfectants and Oxidants Guidance Manual. 1999.
Daniel FB, et al. “Comparative Subchronic Toxicity Studies of Three Disinfectants.”J Am Water Works Ass1990: 10:61-69.
International Search Report, Jun. 20, 2008, 4 pages.

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