Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2000-12-18
2010-12-14
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200
Reexamination Certificate
active
07851163
ABSTRACT:
Immunoassay for the determination of parathyroid hormone activity in a sample, and for the diagnosis, etiology and treatment of calcium metabolism disturbances, osteopathies and hyper- or hypoparathyroidisms. The parathyroid hormone activity is measured with the aid of an antibody which binds to an epitope in the region of the receptor binding structure15to22of the parathyroid hormone, and an antibody which recognizes whether the amino-terminal end1to3of the parathyroid hormone is intact. The assay permits the antagonistic characteristics of some parathyroid hormone fragments to be taken into account.
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Gardella et al. Endocrinology 1993 vol. 132, p. 2024-30.
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Barbier et al. Biochemistry 2000 vol. 39, p. 14522-30.
Blind, E. et al. Measurement of intact human parathyrin by an extracting two-site immunoradiometric assay.Clinical Chemistry, 1987;33(8):1376-1381.
Mägerlein, M. et al. A new immunoenzymometric assay for bioactive N-terminal human parathyroid hormone fragments and its application in pharmacokinetic studies in dogs.Arzneimittelforschung, Feb. 1998;48(2):199-204.
Re-examination of US-6,030,790, Control No. 90007412.
Armbruster Franz Paul
Missbichler Albert
Roth Heinz-Jürgen
Schmidt-Gayk Heinrich
Cheu Jacob
Immundiagnostik AG
Lahive & Cockfield LLP
Remillard, Esq. Jane E.
Sloper, Esq. Jill Gorny
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