Method for determining the biological activity of defibrotide

Details Method for determining the biological activity of defibrotide Method for determining the biological activity of defibrotide

2004-06-17

2008-03-04

Gitomer, Ralph (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C514S04400A

Reexamination Certificate

active

07338777

ABSTRACT:
Method for determining the biological activity of defibrotide by a) bringing into contact defibrotide, plasmin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide.

REFERENCES:
patent: 4234682 (1980-11-01), Bartl et al.
patent: 5231006 (1993-07-01), Kolde
patent: WO 99/12935 (1999-03-01), None
patent: WO 03/052130 (2003-06-01), None
Porta, R. et al; “High-Performance Liquid Chromatography Determination of Polydeoxyribonucleotides in Plasma: Its application to the Determination of Defibrotide's Pharmacokinetics in the Rabbit”;Analytical Biochemistry; vol. 204, pp. 143-146 (1992).

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